Regulation of adrenocorticotropic hormone secretion: lessons from mice deficient in corticotropin-releasing hormone
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چکیده
منابع مشابه
Regulation of adrenocorticotropic hormone secretion: lessons from mice deficient in corticotropin-releasing hormone.
words of Hans Selye from the 1940s still ring true today. Selye recognized that physical, emotional, and environmental challenges (stressors) elicit a variety of physiological responses and that our ability to respond and adapt to these stressors is critical to our survival. In the 50 years since these initial observations, we have learned a great deal about the complex system that allows us to...
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Corticotropin-releasing hormone (CRH), also known as corticotropin-releasing factor, is a highly conserved peptide hormone comprising 41 amino acid residues. Its name derives from its role in the anterior pituitary, where it mediates the release of corticotropin (ACTH) leading to the release of adrenocortical steroids. CRH is the major hypothalamic activator of the hypothalamic–pituitary– adren...
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Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes. In this review we focus on the diverse structural...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2000
ISSN: 0021-9738
DOI: 10.1172/jci10002